Acetic Anhydride → N-(3,5-dimethoxyphenyl)acetamide

HRID 912548

반응식

HRID 912548 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:11])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[CH3:12][C:13](OC(C)=O)=[O:14].CCCCCC>C1(C)C=CC=CC=1>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([NH:11][C:13](=[O:14])[CH3:12])[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=1

참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 8058HexaneHCID 663013,5-Dimethoxyaniline

생성물 1

HCID 702039N-(3,5-dimethoxyphenyl)acetamide

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of 3,5-dimethoxy-phenylamine (22.0 g, 143.6 mmol) in toluene (100 mL), is added slowly Ac2O (14 mL) at room temperature. After stirring 30 minutes, hexane (50 mL) is added with stirring at room temperature. The resulting solid is filtered and washed with hexane (50 mL) to offer designed product as a white solid 14.

후처리

  1. stirringwith stirring at room temperature
  2. filtrationThe resulting solid is filtered
  3. washwashed with hexane (50 mL)

출처 및 근거

ORD 기록
ord-64bcb4283a7945a9bd9298d6aa0737d0
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026243B2

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