Iodoethane → 3-Ethoxy-2-methyl-4H-pyran-4-one

HRID 912653노트

반응식

HRID 912653 반응식
[OH:1][C:2]1[C:7](=[O:8])[CH:6]=[CH:5][O:4][C:3]=1[CH3:9].[OH-].[Na+].[CH2:12](I)[CH3:13]>CO.O>[CH2:12]([O:1][C:2]1[C:7](=[O:8])[CH:6]=[CH:5][O:4][C:3]=1[CH3:9])[CH3:13]

참가 물질

6

반응물 3

HCID 6340IodoethaneHCID 8369MaltolHCID 14798Sodium Hydroxide

생성물 1

HCID 98340133-Ethoxy-2-methyl-4H-pyran-4-one수율 71.1%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

3-Hydroxy-2-methyl-4-pyrone (10 g, 79.4 mmol) was dissolved in methanol (10 mL) and sodium hydroxide (3.49 g, 87.3 mmol) in water (8 mL) was added, followed by ethyl iodide (6.97 mL, 87.3 mmol). The reaction mixture was stirred under reflux overnight. The reaction mixture was then partitioned between water (50 mL) and CH2Cl2 (100 mL). The organic phase was washed with sodium hydroxide (5%, aq.), water, dried (MgSO4) and evaporated to give the title product (8.7 g, 71%) as a solid. The crude product was used in the next step without further purification.

후처리

  1. temperatureunder reflux overnight
  2. customThe reaction mixture was then partitioned between water (50 mL) and CH2Cl2 (100 mL)
  3. washThe organic phase was washed with sodium hydroxide (5%, aq.), water
  4. dry with materialdried (MgSO4)
  5. customevaporated

출처 및 근거

ORD 기록
ord-eb17e2879cbb458f92d7c828803f90e4
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026244B2

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