1-Butanol → N-(3-fluorophenyl)-6-iodo-4-pyrimidinamine
반응식
I[C:2]1[CH:7]=[C:6]([I:8])[N:5]=[CH:4][N:3]=1.[F:9][C:10]1[CH:11]=[C:12]([CH:14]=[CH:15][CH:16]=1)[NH2:13].C(N(CC)C(C)C)(C)C.C(O)CCC>O>[F:9][C:10]1[CH:11]=[C:12]([NH:13][C:2]2[CH:7]=[C:6]([I:8])[N:5]=[CH:4][N:3]=2)[CH:14]=[CH:15][CH:16]=1참가 물질
6
반응 조건
- 온도
- 120 °C
실험 절차
A mixture of 4,6-diiodopyrimidine (1.0 g, 3.01 mmol), 3-fluoroaniline (290 μL, 3.01 mmol), N,N-diisopropylethylamine (782 μL, 4.52 mmol) and n-butanol (3 mL) under nitrogen was stirred at 120° C. for 4 h. After cooling to room temperature, the solution was poured into water and extracted with ethyl acetate. The organic layer was washed once with 1 N hydrochloric acid, followed by brine, dried and concentrated to yield 0.68 g of title compound.
후처리
- temperatureAfter cooling to room temperature
- extractionextracted with ethyl acetate
- washThe organic layer was washed once with 1 N hydrochloric acid
- customdried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-95c9daeeea0347cba96e69ac48d42b30
- 출처 데이터셋
- uspto-grants-2011_09
- 특허 번호
- US08026359B2
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