Hydrogen Bromide → 4-Amino-2-ethylthiazolo[4,5-c]quinolin-7-ol

HRID 913359노트

반응식

HRID 913359 반응식
C([O:8][C:9]1[CH:10]=[CH:11][C:12]2[C:13]3[S:22][C:21]([CH2:23][CH3:24])=[N:20][C:14]=3[C:15]([NH2:19])=[N:16][C:17]=2[CH:18]=1)C1C=CC=CC=1.Br.[OH-].[Na+]>C(O)(=O)C>[NH2:19][C:15]1[C:14]2[N:20]=[C:21]([CH2:23][CH3:24])[S:22][C:13]=2[C:12]2[CH:11]=[CH:10][C:9]([OH:8])=[CH:18][C:17]=2[N:16]=1

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 14798Sodium HydroxideHCID 589650297-Benzyloxy-2-ethylthiazolo[4,5-c]quinolin-4-amine

생성물 1

HCID 1363391164-Amino-2-ethylthiazolo[4,5-c]quinolin-7-ol수율 101.6%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
65 °C

실험 절차

To a round bottom flask containing 7-benzyloxy-2-ethylthiazolo[4,5-c]quinolin-4-amine (11.3 g, 33.7 mmol) was added a 45 wt. % solution of hydrogen bromide in acetic acid (40 mL). The resulting solution was heated at 65° C. for 2 hours and then cooled in an ice bath. Aqueous sodium hydroxide (50% w/w solution) was added slowly until pH 7 and a pale yellow/green solid formed. The solid was isolated by filtration and air dried to provide 8.4 g of 4-amino-2-ethylthiazolo[4,5-c]quinolin-7-ol. MS (APCI) m/z=246.0.

후처리

  1. temperaturecooled in an ice bath
  2. customa pale yellow/green solid formed
  3. customThe solid was isolated by filtration and air
  4. customdried

출처 및 근거

ORD 기록
ord-53ef13f7b8314f9eac63bc1417a9007a
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026366B2

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