Hydrochloric Acid → 3-amino-N,N-dimethylbenzylamine
반응식
[CH3:1][N:2]([CH3:13])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-])=O)[CH:5]=1.Cl.Cl[Sn]Cl>CO>[CH3:13][N:2]([CH2:3][C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][CH:9]=1)[NH2:10])[CH3:1]참가 물질
5
실험 절차
To a solution of 11 (1.2 g, 6.67 mmol) in methanol (100 mL) were sequentially added conc. HCl (10 mL) and SnCl2 (5 g, 26.67 mmol). The reaction mixture was stirred at room temperature overnight before it was partitioned between water and EtOAc (200 mL each). The organic layer was separated and washed with water (150 mL), brine (150 mL) and dried over Na2SO4. The solids were filtered and the filtrate was concentrated on a rotavap to give 12 (500 mg).
후처리
- customwas partitioned between water and EtOAc (200 mL each)
- customThe organic layer was separated
- washwashed with water (150 mL), brine (150 mL)
- dry with materialdried over Na2SO4
- filtrationThe solids were filtered
- concentrationthe filtrate was concentrated on a rotavap
출처 및 근거
- ORD 기록
- ord-eec84e5c1d714d66918bd10e24a6ffeb
- 출처 데이터셋
- uspto-grants-2007_09
- 특허 번호
- US07265122B2
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