Hydrochloric Acid → 2-(2-Nitrovinyl)-5-phenylfuran

HRID 915648

반응식

HRID 915648 반응식
[C:1]1([C:7]2[O:11][C:10]([CH:12]=O)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO.[OH-].[Na+].Cl.[N+:19]([CH3:22])([O-:21])=[O:20]>O>[N+:19]([CH:22]=[CH:12][C:10]1[O:11][C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:8][CH:9]=1)([O-:21])=[O:20]

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6375NitromethaneHCID 14798Sodium HydroxideHCID 27694205-Phenyl-2-furaldehyde

생성물 1

HCID 8012792-(2-Nitrovinyl)-5-phenylfuran

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

Combine 5-phenylfuran-2-carbaldehyde (808 mg, 4.69 mmol), methanol (2.0 mL), and nitromethane (1.13 mL) and cool. Add a combination of 0.20 mL of 1M sodium hydroxide and 0.70 mL of water to the reaction. Stir the reaction for 15 minutes, dilute with water (5 mL), add 1.0 mL of concentrated hydrochloric acid, and stir for 20 additional hours. Extract the reaction with ethyl acetate, dry organics, filter and evaporate to yield 1.14 g of 2-(2-nitrovinyl)-5-phenylfuran as a brown oil which can be used without further purification. MH+ 216.0

후처리

  1. customto the reaction
  2. customthe reaction for 15 minutes
  3. stirringstir for 20 additional hours
  4. extractionExtract
  5. customthe reaction with ethyl acetate
  6. filtrationdry organics, filter
  7. customevaporate

출처 및 근거

ORD 기록
ord-3025f83ffd4745d8b39fa8720adb10a3
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07265246B2

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