1-Amino-2-propanol → N-(2-hydroxypropyl)benzamide

HRID 915664노트

반응식

HRID 915664 반응식
[NH2:1][CH2:2][CH:3]([OH:5])[CH3:4].CCN(C(C)C)C(C)C.[C:15](Cl)(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(Cl)Cl>[OH:5][CH:3]([CH3:4])[CH2:2][NH:1][C:15](=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

5

반응물 3

HCID 41-Amino-2-propanolHCID 7412Benzoyl chlorideHCID 81531Diisopropylethylamine

생성물 1

HCID 10910143N-(2-hydroxypropyl)benzamide수율 83.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Prepare a solution of 1-amino-2-propanol (5.0 g, 66.6 mmol) in methylene chloride (250 mL) at 0° C. under nitrogen. Add Hünig's Base (11.6 mL, 66.6 mmol) followed by benzoyl chloride (7.7 mL, 66.6 mmol). Warm the reaction mixture to room temperature and stir overnight. Wash the solution sequentially with brine (100 mL) and 1M HCl (75 mL), dry (Na2SO4), filter, and concentrate to afford 10.0 g of N-(2-hydroxypropyl)benzamide. MS: m/e=180 (MH+)

후처리

  1. washWash the solution sequentially with brine (100 mL) and 1M HCl (75 mL)
  2. dry with materialdry (Na2SO4)
  3. filtrationfilter
  4. concentrationconcentrate

출처 및 근거

ORD 기록
ord-1720d19d049141adb3d8182c3e3dac2d
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07265246B2

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