2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → N-Ethyl-N'-(8H-[1,3]thiazolo[4,5-g]indol-2-yl)urea

HRID 9157

반응식

HRID 9157 반응식
[S:1]1[C:12]2[C:11]3[NH:10][CH:9]=[CH:8][C:7]=3[CH2:6][CH2:5][C:4]=2[N:3]=[C:2]1[NH:13][C:14]([NH:16][CH2:17][CH3:18])=[O:15].C(C1C(=O)C(Cl)=C(Cl)C(=O)C=1C#N)#N>C1(C)C=CC=CC=1>[CH2:17]([NH:16][C:14]([NH:13][C:2]1[S:1][C:12]2[C:11]3[NH:10][CH:9]=[CH:8][C:7]=3[CH:6]=[CH:5][C:4]=2[N:3]=1)=[O:15])[CH3:18]

참가 물질

4

반응물 2

HCID 67752,3-Dichloro-5,6-dicyano-1,4-benzoquinoneHCID 21985605N-(5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)-N'-ethylurea

생성물 1

HCID 21985599N-Ethyl-N'-(8H-[1,3]thiazolo[4,5-g]indol-2-yl)urea

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
45 °C

실험 절차

To a suspension of N-(5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)-N′-ethylurea (81 mg, 0.308 mmol) in toluene (3.5 mL) was added DDQ (78 mg, 0.34 mmol). The reaction mixture was stirred at about 45° C. for about 4 hrs. The reaction mixture was pumped down and the crude material was purified by preparative HPLC. 3 mg (4%, 2 steps) pure product was isolated. LC/MS 262 (MH+); RP-BPLC RT 10.45 min.

후처리

  1. customthe crude material was purified by preparative HPLC
  2. custom3 mg (4%, 2 steps) pure product was isolated
  3. customRP-BPLC RT 10.45 min.

출처 및 근거

ORD 기록
ord-5a0dc76b8b9c408797b9d2afd2580814
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091227B2

연결된 노트

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