5-Bromo-2,3-dihydro-1-benzofuran → 4-(5-Bromo-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid ethyl ester

HRID 916017노트

반응식

HRID 916017 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1.[CH2:11]([O:13][C:14](=[O:25])[C:15]([OH:24])([C:20]([F:23])([F:22])[F:21])[CH2:16][C:17]([CH3:19])=[CH2:18])[CH3:12].[Cl-].[Al+3].[Cl-].[Cl-]>C(=S)=S>[CH2:11]([O:13][C:14](=[O:25])[C:15]([OH:24])([C:20]([F:23])([F:22])[F:21])[CH2:16][C:17]([C:4]1[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=[C:2]([Br:1])[CH:3]=1)([CH3:19])[CH3:18])[CH3:12]

참가 물질

5

반응물 3

HCID 27761595-Bromo-2,3-dihydro-1-benzofuranHCID 6451240Aluminum(III) ChlorideHCID 17935595Ethyl 2-hydroxy-4-methyl-2-(trifluoromethyl)pent-4-enoate

생성물 1

HCID 589599534-(5-Bromo-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid ethyl ester

시약·촉매·용매 1

HCID 6348Carbon Disulfide용매

실험 절차

4-(5-Bromo-2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid ethyl ester was prepared using the procedure described in Example 1 with 5-bromo-2,3-dihydrobenzofuran and 2-hydroxy-4-methyl-2-trifluoromethylpent-4-enoic acid ethyl ester in carbon disulfide with aluminum chloride.

출처 및 근거

ORD 기록
ord-3b1231a0b9f8450e974204fa1a0ea3e4
출처 데이터셋
uspto-grants-2007_09
특허 번호
US07268152B2

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