Hydrochloric Acid → Methyl 4-aminobenzenebutanoate

HRID 916497

반응식

HRID 916497 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:4][CH:3]=1.Cl.[C:15]([O-])(O)=O.[Na+].C([O-])([O-])=O.[Na+].[Na+]>CO>[CH3:15][O:12][C:11](=[O:13])[CH2:10][CH2:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([NH2:1])=[CH:7][CH:6]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 270494-(4-Aminophenyl)butanoic acidHCID 516892Sodium Bicarbonate

생성물 1

HCID 88628Methyl 4-aminobenzenebutanoate수율 91%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

To a solution of 4-(4-aminophenyl)-butyric acid (5 g, 27.90 mmol) in MeOH (100 mL) at room temperature was added HCl conc. (37% 15 mL). The resulting mixture was stirred overnight at 50° C. then treated with a saturated aqueous solution NaHCO3 and Na2CO3 solid until pH 9. The solvent was evaporated under reduced pressure then the aqueous phase was extracted several times with CH2Cl2. The crude material was purified by flash chromatography using CH2Cl2/MeOH as solvent mixture yielding 40 (4.93 g, 91%) as orange solid.

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. extractionthe aqueous phase was extracted several times with CH2Cl2
  3. customThe crude material was purified by flash chromatography

출처 및 근거

ORD 기록
ord-c8e20f890da04c3e8d60e09bd7268c1d
출처 데이터셋
uspto-grants-2007_09
특허 번호
USRE039850E1

연결된 노트

불러오는 중…