Acetic Anhydride → 2-[4-(2-Bromoethyl)phenoxy]ethyl acetate
반응식
[Br:1][CH2:2][CH2:3][C:4]1[CH:13]=[CH:12][C:7]([O:8][CH2:9][CH2:10][OH:11])=[CH:6][CH:5]=1.[C:14](OC(=O)C)(=[O:16])[CH3:15].C(N(CC)CC)C>CN(C1C=CN=CC=1)C.C(Cl)Cl>[C:14]([O:11][CH2:10][CH2:9][O:8][C:7]1[CH:12]=[CH:13][C:4]([CH2:3][CH2:2][Br:1])=[CH:5][CH:6]=1)(=[O:16])[CH3:15]참가 물질
6
실험 절차
A mixture of 2-[4-(2-bromoethyl)phenoxy]ethanol (900 mg), acetic anhydride (0.5 mL), triethylamine (1.0 mL) and DMAP (13 mg) in DCM (5 mL) was stirred at room temperature for 0.5 h. The reaction was quenched by pouring into aq. NaHCO3 and the organic layer was washed with 2M HCl, dried (MgSO4) and concentrated in vacuo to give the title compound (1.03 g). LCMS RT=3.32 min.
후처리
- customThe reaction was quenched
- additionby pouring into aq. NaHCO3
- washthe organic layer was washed with 2M HCl
- dry with materialdried (MgSO4)
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-8d581ef81ae6458c93bdd9de33d20e6e
- 출처 데이터셋
- uspto-grants-2007_09
- 특허 번호
- US07271197B2
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