Hydrochloric Acid → 3-[4-(Hydroxymethyl)phenyl]propanoic acid
반응식
C[CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][OH:14])=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4].[Li+].[OH-].Cl>CO.O>[OH:14][CH2:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][CH2:2][C:3]([OH:5])=[O:4])=[CH:8][CH:9]=1참가 물질
6
실험 절차
Intermediate B (5 g, 25.7 mmol) was dissolved in MeOH (50 mL) and water (10 mL). LiOH (1.85 g, 77.2 mmol) was added and the reaction stirred at RT for 18 h. The reaction mixture was acidified to pH ˜3 with 1M HCl, the resulting precipitate was isolated by filtration to afford the desired product (4.57 g, quant.). 1H NMR (300 MHz, d6-DMSO) δ: 7.18 (4H, q), 4.45 (2H, d), 2.81 (2H, t), 2.62 (2H, t).
후처리
- customthe resulting precipitate was isolated by filtration
출처 및 근거
- ORD 기록
- ord-3e276ce1c7c5425b982a303dbcf8dc8b
- 출처 데이터셋
- uspto-grants-2016_03
- 특허 번호
- US09273003B2
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