Acetyl chloride → 1-(6-Methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)ethan-1-one

HRID 922440노트

반응식

HRID 922440 반응식
[CH3:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[CH:10][C:5]2=[CH:4][CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].[C:15](Cl)(=[O:17])[CH3:16].C(=O)([O-])O.[Na+]>ClC(Cl)C>[CH3:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[C:10]([C:15](=[O:17])[CH3:16])[C:5]2=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 6367Acetyl chlorideHCID 516892Sodium BicarbonateHCID 6451240Aluminum(III) ChlorideHCID 114577166-Methyl-1H-pyrrolo[2,3-b]pyridine

생성물 1

HCID 683086561-(6-Methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)ethan-1-one

시약·촉매·용매 1

HCID 63651,1-Dichloroethane용매

실험 절차

To a solution of 6-methyl-1H-pyrrolo[2,3-b]pyridine (500 mg) in dichloroethane (6 mL) were added aluminum chloride (1.09 g) and acetyl chloride (0.40 mL), and then the mixture was stirred at room temperature for 1.5 hours. The reaction solution was poured into aqueous saturated sodium hydrogen carbonate solution, and extracted with chloroform. The organic layer was washed with saturated saline, dried over magnesium sulfate, and then concentrated under reduced pressure. The resulting residue was triturated with isopropyl ether to 1-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone [REx(8-1)] (481 mg) as a yellow powder.

후처리

  1. extractionextracted with chloroform
  2. washThe organic layer was washed with saturated saline
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customThe resulting residue was triturated with isopropyl ether to 1-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone [REx(8-1)] (481 mg) as a yellow powder

출처 및 근거

ORD 기록
ord-b6a6fd5c48e14501bfbf662271d3427f
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09278944B2

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