Hydrochloric Acid → 2-Fluoro-4-formyl-6-hydroxybenzoic acid

HRID 924662노트

반응식

HRID 924662 반응식
[F:1][C:2]1[CH:11]=[C:10]([CH:12]=[O:13])[CH:9]=[C:8]([OH:14])[C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+].Cl.CCO>CO>[F:1][C:2]1[CH:11]=[C:10]([CH:12]=[O:13])[CH:9]=[C:8]([OH:14])[C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 86669343Methyl 2-fluoro-4-formyl-6-hydroxybenzoate2회

생성물 1

HCID 866815012-Fluoro-4-formyl-6-hydroxybenzoic acid

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
20 °C

실험 절차

A mixture of methyl 2-fluoro-4-formyl-6-hydroxybenzoate (Intermediate 7) (300 mg, 1.50 mmol) and aqueous NaOH (2 M, 10 mL) in MeOH (10 mL) was stirred at 20° C. for 5 hours. The mixture was acidified with aqueous HCl until pH=2 followed by a standard aqueous/EtOH workup. The residue was used for next step without further purification.

후처리

  1. customThe residue was used for next step without further purification

출처 및 근거

ORD 기록
ord-ad1ccf40f5e240cf85ac44fdce450753
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09283213B2

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