Propionic Acid → 3-Fluoro-2,6-dipropyl-4-propionylphenol

HRID 9252

반응식

HRID 9252 반응식
[C:1](O)(=O)[CH2:2][CH3:3].[F:6][C:7]1[C:8]([CH2:17][CH2:18][CH3:19])=[C:9]([OH:16])[CH:10]=[CH:11][C:12]=1[CH2:13][CH2:14][CH3:15].FC(F)(F)S(O)(=O)=[O:23]>>[F:6][C:7]1[C:8]([CH2:17][CH2:18][CH3:19])=[C:9]([OH:16])[C:10]([CH2:1][CH2:2][CH3:3])=[CH:11][C:12]=1[C:13](=[O:23])[CH2:14][CH3:15]

참가 물질

4

반응물 3

HCID 1032Propionic AcidHCID 62406Trifluoromethanesulfonic acidHCID 219859573-Fluoro-2,4-dipropylphenol

생성물 1

HCID 219859433-Fluoro-2,6-dipropyl-4-propionylphenol

실험 절차

Propionic acid (9.07 g, 123 mmol) and 3-fluoro-2,4-dipropylphenol (9.60 g, 49.0 mmol) were mixed in trifluoromethanesulfonic acid (50 mL) as in Example 13, step 1. Purification by chramotography on silica gel using ethyl acetate:hexane (10:90) gave the title compound as a white solid.

후처리

  1. customPurification by chramotography on silica gel

출처 및 근거

ORD 기록
ord-f951ff6e45a44e29983784a13e42f834
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091230B2

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