Hydrochloric Acid → 2-(Benzo[b]thiophen-2-ylmethyl)malonic acid

HRID 926508노트

반응식

HRID 926508 반응식
[S:1]1[C:5]([CH2:6][CH:7]2[C:12](=[O:13])[O:11]C(C)(C)[O:9][C:8]2=[O:16])=[CH:4][C:3]2[CH:17]=[CH:18][CH:19]=[CH:20][C:2]1=2.[OH-].[Na+].Cl>>[S:1]1[C:5]([CH2:6][CH:7]([C:12]([OH:13])=[O:11])[C:8]([OH:16])=[O:9])=[CH:4][C:3]2[CH:17]=[CH:18][CH:19]=[CH:20][C:2]1=2

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 867155895-(Benzo[b]thiophen-2-ylmethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

생성물 1

HCID 867155902-(Benzo[b]thiophen-2-ylmethyl)malonic acid

실험 절차

A solution of 5-(benzo[b]thiophen-2-ylmethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (2.0 g, 6.88 mmol, Intermediate 39: step a) and 3 M aqueous NaOH (14 mL) was heated in a 102° C. oil bath for 28 hours. The reaction mixture was poured over ice and acidified to pH 1 with concentrated aqueous HCl. The suspension was stirred at room temperature for 2 hours then filtered rinsing further with water and dried to provide the title compound as a tan solid.

후처리

  1. additionThe reaction mixture was poured over ice
  2. filtrationthen filtered
  3. washrinsing further with water
  4. customdried

출처 및 근거

ORD 기록
ord-4b57ce36f3c944c38da91b8860747c0a
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09284308B2

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