Hydrazine hydrate (1:1) → 6-(1H-1,2,4-Triazol-1-yl)pyridin-3-amine

HRID 926735

반응식

HRID 926735 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)=[N:8][CH:9]=1)([O-])=O.O.NN>[Ni].C(O)C.CO>[N:10]1([C:7]2[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)[CH:14]=[N:13][CH:12]=[N:11]1

참가 물질

6

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 27667645-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine

생성물 1

HCID 167723276-(1H-1,2,4-Triazol-1-yl)pyridin-3-amine

시약·촉매·용매 3

HCID 935Nickel촉매HCID 702Ethanol용매HCID 887Methanol용매

실험 절차

Raney nickel (0.650 g) was added to a solution of 5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine (3.2 g, 16.7 mmol) in a mixture of ethanol and methanol (1:1) (150 mL) followed by the addition of Hydrazine hydrate (2.51 g, 50.2 mmol) and stirring was continued at 25° C. 1 hr. The reaction mixture was filtered over celite bed and washed with methanol. The filtrate and the washings were concentrated under reduced pressure to afford title compound as pale brown liquid. MS (ESI): m/z 162.1 (M+H).

후처리

  1. customwas continued at 25° C
  2. custom1 hr
  3. filtrationThe reaction mixture was filtered over celite bed
  4. washwashed with methanol
  5. concentrationThe filtrate and the washings were concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e0ba472449004b1f9bcbfae8f21479ea
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09289419B2

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