Hydrochloric Acid → 6-(3-Chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acid

HRID 927430

반응식

HRID 927430 반응식
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[CH2:13][CH2:12]2)=[C:7]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=2)[N:6]=1)=[O:4].[OH-].[Na+].Cl>O>[Cl:20][C:16]1[CH:15]=[C:14]([C:7]2[N:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:10]=[CH:9][C:8]=2[CH:11]2[CH2:12][CH2:13]2)[CH:19]=[CH:18][CH:17]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 710879366-(3-Chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acid methyl ester

생성물 1

HCID 710874536-(3-Chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acid수율 78.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

6-(3-Chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acid methyl ester (80 mg, 0.28 mmol) and sodium hydroxide (CAN 1310-73-2, 30 mg,) was added into water (10 mL). The mixture was stirred for 2 h at ambient temperature. Subsequently the pH was adjusted to 3 with 1M hydrochloric acid, the mixture extracted with ethyl acetate (3×10 mL), the organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give product (60 mg, 78%); MS (EI): m/e 274.1 [M+H]+.

후처리

  1. extractionthe mixture extracted with ethyl acetate (3×10 mL)
  2. dry with materialdried over anhydrous sodium sulfate
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2b0f4b6e4cd941cd93863b5f8c4f32ea
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290451B2

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