Hydrochloric Acid → 4-bromo-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one

HRID 930835

반응식

HRID 930835 반응식
[Br:1][C:2]1[CH:7]=[N:6][C:5]([O:8]C)=[C:4]2[N:10]([S:13]([C:16]3[CH:22]=[CH:21][C:19]([CH3:20])=[CH:18][CH:17]=3)(=[O:15])=[O:14])[CH:11]=[CH:12][C:3]=12.Cl>O1CCOCC1>[Br:1][C:2]1[C:3]2[CH:12]=[CH:11][N:10]([S:13]([C:16]3[CH:22]=[CH:21][C:19]([CH3:20])=[CH:18][CH:17]=3)(=[O:15])=[O:14])[C:4]=2[C:5](=[O:8])[NH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 896575464-bromo-7-methoxy-1-tosyl-1H-pyrrolo[2,3-c]pyridine

생성물 1

HCID 896575804-bromo-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one수율 94%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

반응 조건

온도
40 °C

실험 절차

A solution of Example 1c (12.4 g, 32.6 mmol) in dioxane (140 mL) was stirred at room temperature. To this solution was added 4M HCl in dioxane (140 mL). The reaction mixture was stirred at 40° C. for 16 hours. The reaction mixture was cooled to room temperature and concentrated. The residue was triturated with diethylether, filtered, and rinsed with additional diethylether and dried to provide the title compound (11.23 g, 30.6 mmol, 94% yield) as a beige solid.

후처리

  1. temperatureThe reaction mixture was cooled to room temperature
  2. concentrationconcentrated
  3. customThe residue was triturated with diethylether
  4. filtrationfiltered
  5. washrinsed with additional diethylether
  6. customdried

출처 및 근거

ORD 기록
ord-ede04b1e8a7f40ba94f817619411fce3
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296741B2

연결된 노트

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