Sodium Hydroxide → 4-[4-(Hydroxymethyl)-5-methyl-1,3-oxazol-2-yl]benzoic acid

HRID 931455

반응식

HRID 931455 반응식
Cl[CH2:2][C:3]1[N:4]=[C:5]([C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15]C)=[O:14])=[CH:11][CH:10]=2)[O:6][C:7]=1[CH3:8].[OH-:19].[Na+]>>[OH:19][CH2:2][C:3]1[N:4]=[C:5]([C:9]2[CH:18]=[CH:17][C:12]([C:13]([OH:15])=[O:14])=[CH:11][CH:10]=2)[O:6][C:7]=1[CH3:8]

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 23076573Methyl 4-(4-(chloromethyl)-5-methyloxazol-2-yl)benzoate

생성물 1

HCID 682784254-[4-(Hydroxymethyl)-5-methyl-1,3-oxazol-2-yl]benzoic acid수율 72%

실험 절차

Reaction of chloride 2 (500 mg, 1.88 mmol) and aqueous NaOH (2 M, 10 mL, 20 mmol) gave acid 55 (313 mg, 72%) as a cream solid: mp (EtOAc/MeOH) 240-242° C.; 1H NMR δ □ 13.18 (br s, 1H, CO2H), 8.00-8.06 (m, 4H, H-2, H-3, H-5, H-6), 5.11 (br s, 1H, OH), 2.41 (s, 3H, CH3); MS m/z 234.5 (MH+, 100%); HRMS calcd for C12H12NO4: 234.0761. Found: 234.0760.

출처 및 근거

ORD 기록
ord-7c7e2eadb1e94dbfb764c3b4d32d7c6c
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09296732B2

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