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Hydrochloric Acid → N-(3-chloro-4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazol-5-ylmethyl)indole-2-carboxamide

HRID 963096
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HRID 963096 반응식
[Cl:1][C:2]1[N:6]2[C:7]3[S:21][C:20]([CH2:22][CH3:23])=[CH:19][C:8]=3[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:18])=[N:10][CH2:11][C:5]2=[N:4][N:3]=1.Cl.C(=O)([O-])[OH:26].[Na+].[NH:30]1[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH:32]=[C:31]1[C:39](Cl)=[O:40]>C(Cl)(Cl)Cl>[Cl:1][C:2]1[N:6]([C:7]2[S:21][C:20]([CH2:22][CH3:23])=[CH:19][C:8]=2[C:9](=[O:26])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])[C:5]([CH2:11][NH:10][C:39]([C:31]2[NH:30][C:38]3[C:33]([CH:32]=2)=[CH:34][CH:35]=[CH:36][CH:37]=3)=[O:40])=[N:4][N:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 118162081H-indole-2-carbonyl ChlorideHCID 677277459-chloro-4-(2-chlorophenyl)-2-ethyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine

생성물 1

HCID 67727760N-(3-chloro-4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazol-5-ylmethyl)indole-2-carboxamide

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

9-Chloro-4-(2-chlorophenyl)-2-ethyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine (0.5 g) was stirred with 2M hydrochloric acid (12.5 ml) at 60° C. for 2.5 hours. The reaction mixture was cooled to room temperature. Sodium hydrogencarbonate was added to make the reaction mixture alkaline. Chloroform and indole-2-carbonyl chloride (0.33 g) were added, and the mixture was stirred for 0.5 hour. The organic layer was washed with saturated brine and dried over magnesium sulfate. The solvent was concentrated under reduced pressure, and the obtained residue was crystallized from ethyl acetate to give 0.2 g of N-(3-chloro-4-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl) [1,2,4]triazol-5-ylmethyl)indole-2-carboxamide.

후처리

  1. washThe organic layer was washed with saturated brine
  2. dry with materialdried over magnesium sulfate
  3. concentrationThe solvent was concentrated under reduced pressure
  4. customthe obtained residue was crystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-8876e720e1d9445e883d22a1242ee547
출처 데이터셋
uspto-grants-1998_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05760032

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