Acetic Anhydride → 1-(4-Difluoromethoxyphenyl)-1-(2-fluoro-2(methoxycarbonyl)ethenyl)cyclopropane
반응식
[F:1][CH:2]([F:15])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2([CH:13]=O)[CH2:12][CH2:11]2)=[CH:6][CH:5]=1.C(OC(=O)C)(=O)C.Cl[C:24](Cl)([F:29])[C:25]([O:27][CH3:28])=[O:26]>[Zn].[Cu]Cl.O1CCCC1>[F:1][CH:2]([F:15])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2([CH:13]=[C:24]([F:29])[C:25]([O:27][CH3:28])=[O:26])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1참가 물질
7
실험 절차
The method of Example 1 was repeated using zinc powder (2.8 g), copper (I) chloride (0.42 g), molecular sieve 4A (2.8 g) tetrahydrofuran (50 ml), 1-(4-difluoromethoxyphenyl)-1-formylcyclopropane, acetic anhydride (1.5 ml) and methyl dichlorofluoroacetate (3.6 g) to yield the title compound (0.79 g, 28%).
출처 및 근거
- ORD 기록
- ord-7182948a159947419d437f1f4683d20d
- 출처 데이터셋
- uspto-grants-1998_06
- 특허 번호
- US05763700
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