Sodium borohydride → (4-Chloroquinolin-7-yl)methanol

HRID 965000

반응식

HRID 965000 반응식
C[O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([C:9]([Cl:15])=[CH:10][CH:11]=[N:12]2)=[CH:7][CH:6]=1)=O.[BH4-].[Na+]>CO>[OH:2][CH2:3][C:5]1[CH:14]=[C:13]2[C:8]([C:9]([Cl:15])=[CH:10][CH:11]=[N:12]2)=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 21708520Methyl 4-chloroquinoline-7-carboxylate

생성물 1

HCID 22054610(4-Chloroquinolin-7-yl)methanol수율 30.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

7-Methoxycarbonyl-4-chloroquinoline(3.75 g, 0.017 mol) was dissolved in methanol (200 ml), added under ice-cooling with sodium borohydride (12.9 g, 0.34 mol) and stirred for an hour. The reaction mixture was poured into ice water. The resulting precipitates were collected by filtration, dried over phosphorus pentoxide and recrystallized from chloroform (20 ml) to obtain 1.0 g (30%) of 7-hydroxymethyl-4-chloroquinoline.

후처리

  1. additionadded under ice-
  2. customThe resulting precipitates
  3. filtrationwere collected by filtration
  4. dry with materialdried over phosphorus pentoxide
  5. customrecrystallized from chloroform (20 ml)

출처 및 근거

ORD 기록
ord-46de3671617c45bd83848ffcb82be690
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05773449

연결된 노트

불러오는 중…