Hydrochloric Acid → HCID 21986508, 화합물

HRID 9660노트

반응식

HRID 9660 반응식
[Br:1][C:2]1[S:6][C:5]([C:7](=[O:9])C)=[C:4]([CH3:10])[CH:3]=1.[BH4-].[Na+].Cl>C(O)C>[Br:1][C:2]1[S:6][C:5]([CH2:7][OH:9])=[C:4]([CH3:10])[CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 21986456HCID 21986456, 화합물2회

생성물 1

HCID 21986508HCID 21986508, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
0 °C

실험 절차

A mixture of 1-(5-bromo-3-methylthien-2-yl)ethanone (intermediate 82, 5.13 g) in ethanol (50 ml) was treated with sodium borohydride (0.947 g). The reaction was stirred at 0° C. for 60 minutes and warmed to room temp for 30 minutes. 2M Aqueous hydrochloric acid was added and the reaction mixture was extracted with ethyl acetate twice. The organic solutions were combined and dried with brine and over magnesium sulfate. The title compound was isolated after removal of the desiccant and evaporation of the solvent.

후처리

  1. temperaturewarmed to room temp for 30 minutes
  2. extractionthe reaction mixture was extracted with ethyl acetate twice
  3. dry with materialdried with brine and over magnesium sulfate

출처 및 근거

ORD 기록
ord-52cc4b26200a4c778030d3f61d23cf78
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091237B2

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