Water → HCID 178520452, 화합물

HRID 967753노트

반응식

HRID 967753 반응식
C[N:2]([CH:4]=[N:5][C:6](=[O:15])[CH:7]=[CH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)C.Cl.N[OH:18].[OH-].[Na+].O>C(O)(=O)C>[OH:18][NH:2][CH:4]=[N:5][C:6](=[O:15])[CH:7]=[CH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 3745097N-[(Dimethylamino)methylene]-cinnamamide

생성물 1

HCID 178520452HCID 178520452, 화합물수율 90%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
5 °C

실험 절차

N-[(Dimethylamino)methylene]-cinnamamide (1.0 g, 5.0 mmol) was added to a solution of hydroxylamine hydrochloride (415 mg, 6.0 mmol) in acetic acid (5 mL of 70% aqueous) and aqueous NaOH (1.2 mL, 5 M, 6.0 mmol). After stirring for 1.5 h water (5 mL) was added, and the reaction mixture was cooled to 5° C. in an ice bath. The solution was partitioned between ethyl acetate and water, and the organics were dried over Na2SO4, then concentrated in vacuo to afford N-[(hydroxyamino)methylene]-cinnamamide (850 mg, 90%). This material was carried on to the next step without further purification.

후처리

  1. additionwas added
  2. customThe solution was partitioned between ethyl acetate and water
  3. dry with materialthe organics were dried over Na2SO4
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-8d28f91bda164931a76ed093a67b4430
출처 데이터셋
uspto-grants-2005_10
특허 번호
US06956049B1

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