Stannous Chloride → 4-Benzyloxy-2-fluorophenylhydrazine hydrochloride

HRID 968669

반응식

HRID 968669 반응식
[N:1]([O-])=O.[Na+].[CH2:5]([O:12][C:13]1[CH:19]=[CH:18][C:16]([NH2:17])=[C:15]([F:20])[CH:14]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[Cl:21][Sn]Cl>O.Cl>[ClH:21].[CH2:5]([O:12][C:13]1[CH:19]=[CH:18][C:16]([NH:17][NH2:1])=[C:15]([F:20])[CH:14]=1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

참가 물질

6

반응물 3

HCID 24479Stannous ChlorideHCID 114998094-(Benzyloxy)-2-fluoroanilineHCID 23668193Sodium Nitrite

생성물 1

HCID 116375674-Benzyloxy-2-fluorophenylhydrazine hydrochloride수율 77.2%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매2회HCID 962Water용매

실험 절차

A solution of NaNO2 (1.38 g) in H2O (8 mL) was added to a suspension of 4-benzyloxy-2-fluoroaniline (5.0 g) in 6N HCl (24 mL) at 0° C. After 30 minutes stirring, a solution of SnCl2 (7.7 g) in 6N HCl (24 mL) was added to the mixture at 0° C. The mixture was allowed to warm to room temperature and stirred for 1.5 hours to produce a precipitate. The precipitate was collected by filtration to yield 4.15 g of the title compound.

후처리

  1. stirringstirred for 1.5 hours
  2. customto produce a precipitate
  3. filtrationThe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-48f7b1f6e34446d7bcf428095382b934
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07304072B2

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