Hydrochloric Acid → 6-(2-methoxyethoxymethoxy)-2-naphthoic acid

HRID 969476

반응식

HRID 969476 반응식
[OH-].[Na+].[CH3:3][O:4][CH2:5][CH2:6][O:7][CH2:8][O:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[CH:16]=[C:15]([C:20]([O:22]C)=[O:21])[CH:14]=[CH:13]2.Cl>O1CCCC1.CO.O>[CH3:3][O:4][CH2:5][CH2:6][O:7][CH2:8][O:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[CH:16]=[C:15]([C:20]([OH:22])=[O:21])[CH:14]=[CH:13]2

참가 물질

7

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12085484Methyl 6-(2-methoxyethoxymethoxy)naphthalene-2-carboxylate

생성물 1

HCID 120854856-(2-methoxyethoxymethoxy)-2-naphthoic acid수율 93%

시약·촉매·용매 3

HCID 962Water촉매HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

12.9 g (325 mmol) of sodium hydroxide pellets are added to a solution of 16.9 g (58 mmol) of methyl 6-(2-methoxyethoxymethoxy)naphthalene-2-carboxylate in 200 ml of tetrahydrofuran, 20 ml of methanol and a few drops of water, and the reaction medium is stirred at room temperature for 4 hours. Next, aqueous 1N hydrochloric acid solution is added until pH=2 is obtained, and the reaction medium is extracted with ethyl acetate, dried over sodium sulfate, filtered and concentrated under vacuum. The residue obtained is washed with heptane and filtered. 14.9 g of 6-(2-methoxyethoxymethoxy)-2-naphthoic acid are obtained in the form of a white solid, in a yield of 92%.

후처리

  1. customis obtained
  2. extractionthe reaction medium is extracted with ethyl acetate
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under vacuum
  6. customThe residue obtained
  7. washis washed with heptane
  8. filtrationfiltered

출처 및 근거

ORD 기록
ord-479e6b9a53a245dea2ec7495b60678ca
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07307078B2

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