Hydrochloric Acid → 4-{3-[3,4-Bis(hydroxymethyl)phenyl]propyl}-2-ethylphenol

HRID 970842노트

반응식

HRID 970842 반응식
[CH2:1]([C:3]1[CH:4]=[C:5]([CH2:10][CH2:11][CH2:12][C:13]2[CH:14]=[C:15]([C:23](OC)=[O:24])[C:16](=[CH:21][CH:22]=2)[C:17](OC)=[O:18])[CH:6]=[CH:7][C:8]=1[OH:9])[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+].Cl>C(OCC)C.O>[OH:24][CH2:23][C:15]1[CH:14]=[C:13]([CH2:12][CH2:11][CH2:10][C:5]2[CH:6]=[CH:7][C:8]([OH:9])=[C:3]([CH2:1][CH3:2])[CH:4]=2)[CH:22]=[CH:21][C:16]=1[CH2:17][OH:18]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 17983037Dimethyl 4-[3-(3-ethyl-4-hydroxyphenyl)propyl]phthalateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 694919444-{3-[3,4-Bis(hydroxymethyl)phenyl]propyl}-2-ethylphenol

시약·촉매·용매 2

HCID 962Water용매2회HCID 3283Diethyl Ether용매

실험 절차

1.7 g (4.8 mmol) of dimethyl 4-[3-(3-ethyl-4-hydroxyphenyl)propyl]phthalate (Example 1f are dissolved in 50 ml of ethyl ether, and this solution is slowly added to a suspension of 435 mg (11.4 mmol) of lithium aluminum hydride. The medium is stirred for 30 minutes and is then sequentially treated with 450 μl of water, 450 μl of 15% sodium hydroxide and 1.5 ml of water. The reaction medium is poured into a 1N hydrochloric acid solution, and extracted with ethyl ether. A white solid is obtained (m=1.2 g, m.p.=82° C., y=84%).

후처리

  1. extractionextracted with ethyl ether
  2. customA white solid is obtained (m=1.2 g, m.p.=82° C., y=84%)

출처 및 근거

ORD 기록
ord-4cbc5384fc2742e79d5cd97654289acc
출처 데이터셋
uspto-grants-2007_12
특허 번호
US07312249B2

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