Methyl formate → 2-Hydroxymethylene-17beta-hydroxy-4-methylandrost-4-en-3-one

HRID 971434

반응식

HRID 971434 반응식
O[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@]1(C)C(=C(C)C(=O)CC1)CC3.C(OC)=O.[OH:27][C@@:28]1(C)[CH2:33][CH2:32][C@H:31]2[C@H:34]3[C@H:44]([CH2:45][CH2:46][C@:29]12[CH3:30])[C@:42]1([CH3:43])[C:37](=[C:38]([CH3:50])[C:39](=[O:49])[C:40](=[CH:47][OH:48])[CH2:41]1)[CH2:36][CH2:35]3.[H-].[Na+]>>[OH:48][CH:47]=[C:40]1[CH2:41][C@@:42]2([CH3:43])[C:37]([CH2:36][CH2:35][C@@H:34]3[C@@H:44]2[CH2:45][CH2:46][C@@:29]2([CH3:30])[C@H:31]3[CH2:32][CH2:33][C@@H:28]2[OH:27])=[C:38]([CH3:50])[C:39]1=[O:49]

참가 물질

5

반응물 4

HCID 7865Methyl formateHCID 24758Sodium hydrideHCID 2365364-MethyltestosteroneHCID 573496094,17alpha-Dimethyl-2-hydroxymethylene Testosterone

생성물 1

HCID 706032882-Hydroxymethylene-17beta-hydroxy-4-methylandrost-4-en-3-one

실험 절차

2-Hydroxymethylene-17β-hydroxy-4-methylandrost-4-en-3-one was prepared from 32.28 g. of 17β-hydroxy-4-methylandrost-4-en-3-one and 32 ml. of methyl formate by a procedure analogous to that of Example 1, part (c) except that sodium hydride (15 g., 50%) was used in place of sodium methoxide. The 20 g. of product obtained was used directly in the next reaction.

후처리

  1. customof product obtained
  2. customwas used directly in the next reaction

출처 및 근거

ORD 기록
ord-8c4c7750dc934c27b5fb5795da79a057
출처 데이터셋
uspto-grants-1979_07
특허 번호
US04160027

연결된 노트

불러오는 중…