1-(2-Bromoethyl)-2-methyl-5-nitroimidazole → Tinidazole
반응식
Br[CH2:2][CH2:3][N:4]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][N:6]=[C:5]1[CH3:12].[Na].[CH2:14]([S:16]([OH:18])=[O:17])[CH3:15]>CS(C)=O>[CH2:14]([S:16]([CH2:2][CH2:3][N:4]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][N:6]=[C:5]1[CH3:12])(=[O:18])=[O:17])[CH3:15]참가 물질
5
실험 절차
5.83 g. (25 m moles) of 1-(2'-bromoethyl)-2-methyl-5-nitroimidazole is dissolved in 50 ml. of dimethylsulfoxide and 5.48 g. (30 m mole) of the sodium salt of ethyl sulfinic acid (CH3CH2SO2Na) is added. The reaction mixture is maintained for 21/2 hours at 100°-110° C. thereafter the solvent is removed under vacuum and the solid residue is washed with water and recrystallized from ethanol. The yield is 2.28 (37%) of 1-[2'-(ethylsulfonyl)-ethyl]-2-methyl-5-nitroimidazole, M.P. 124°-126° C.
후처리
- temperatureThe reaction mixture is maintained for 21/2 hours at 100°-110° C.
- customthe solvent is removed under vacuum
- washthe solid residue is washed with water
- customrecrystallized from ethanol
출처 및 근거
- ORD 기록
- ord-7acfe97b781245468d9dddf48f2cda21
- 출처 데이터셋
- uspto-grants-1979_07
- 특허 번호
- US04160096
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