Hydrochloric Acid → 4-Aminomethyl-1-ethyl-1,2,3,6-tetrahydropyridine

HRID 973996노트

반응식

HRID 973996 반응식
C([NH:4][CH2:5][C:6]1[CH2:7][CH2:8][N:9]([CH2:12][CH3:13])[CH2:10][CH:11]=1)(=O)C.[OH-].[Na+].Cl>CO>[NH2:4][CH2:5][C:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH3:13])[CH2:8][CH:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 150234574-Acetylaminomethyl-1-ethyl-1,2,3,6-tetrahydropyridine

생성물 1

HCID 150234584-Aminomethyl-1-ethyl-1,2,3,6-tetrahydropyridine수율 92.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 4-acetylaminomethyl-1-ethyl-1,2,3,6-tetrahydropyridine (20.0 g) and 6N aqueous solution of sodium hydroxide (73 ml) in methanol (150 ml) was refluxed for 40 hours. The solution was acidified with concentrated hydrochloric acid under ice cooling and evaporated in vacuo. To the residue was added ethanol (400 ml) and the mixture was refluxed for an hour. The resulting precipitates were filtered off and the filtrate was evaporated in vacuo. The residue was treated with Amberlite IRA-910 (trademark: Rohm & Haas Co.) and purified by vacuum distillation to give 4-aminomethyl-1-ethyl-1,2,3,6-tetrahydropyridine (14.25 g).

후처리

  1. customevaporated in vacuo
  2. additionTo the residue was added ethanol (400 ml)
  3. temperaturethe mixture was refluxed for an hour
  4. customThe resulting precipitates
  5. filtrationwere filtered off
  6. customthe filtrate was evaporated in vacuo
  7. additionThe residue was treated with Amberlite IRA-910 (trademark: Rohm & Haas Co.)
  8. distillationpurified by vacuum distillation

출처 및 근거

ORD 기록
ord-fe3df2e00a644707aa404ea53cedf97d
출처 데이터셋
uspto-grants-1991_11
특허 번호
US05066680

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