Hydrochloric Acid → 1-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethene

HRID 975062

반응식

HRID 975062 반응식
[O:1]1[CH:5]=[CH:4][C:3]([C:6]([C:9]2[O:13][CH:12]=[N:11][C:10]=2[CH3:14])(O)[CH3:7])=[CH:2]1.Cl.C(OCC)C.C(=O)([O-])O.[Na+]>C(Cl)(Cl)Cl>[O:1]1[CH:5]=[CH:4][C:3]([C:6]([C:9]2[O:13][CH:12]=[N:11][C:10]=2[CH3:14])=[CH2:7])=[CH:2]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 516892Sodium BicarbonateHCID 97941531-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethanol

생성물 1

HCID 189362911-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethene

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

1-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethanol (900 mg) in dry chloroform was treated with 1M anhydrous hydrogen chloride in diethylether (1.1 equivalents). After 10 minutes at room temperature, aqueous sodium hydrogen carbonate was added and the mixture was extracted with dichloromethane. The material thus obtained was purified by flash chromatography to give the title compound as an almost colourless liquid.

후처리

  1. extractionthe mixture was extracted with dichloromethane
  2. customThe material thus obtained
  3. customwas purified by flash chromatography

출처 및 근거

ORD 기록
ord-21c6a0acc52841ffa5708d6978258dba
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05607956

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