Hydrochloric Acid → D-Aspartic acid, N-(phenylmethyl)-3-((phenylmethyl)amino)-, (3S)-rel-

HRID 976019노트

반응식

HRID 976019 반응식
[C@H:1](Br)([C:7]([OH:9])=[O:8])[C@H:2](Br)[C:3]([OH:5])=[O:4].[CH2:11]([NH2:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.Cl>>[CH2:11]([NH:18][CH:2]([CH:1]([NH:18][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:7]([OH:9])=[O:8])[C:3]([OH:5])=[O:4])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 7504BenzylamineHCID 6416112,3-Dibromosuccinic acid, meso-

생성물 1

HCID 108349D-Aspartic acid, N-(phenylmethyl)-3-((phenylmethyl)amino)-, (3S)-rel-

반응 조건

온도
50 °C

실험 절차

To a mechanically stirred solution of meso-2,3-dibromosuccinic acid (27.6 g, 0.100 mol) in alcohol (200 ml) was slowly added benzylamine (85 g, 0.80 mol) at ambient temperature. After complete addition the mixture was refluxed overnight. A heavy precipitate of salts appeared. The mixture was cooled to 50° C. and concentrated hydrochloric acid was added until pH was 4-5. The precipitate was filtered off, washed several times with water and alcohol and dried.

후처리

  1. customat ambient temperature
  2. additionAfter complete addition the mixture
  3. temperaturewas refluxed overnight
  4. filtrationThe precipitate was filtered off
  5. washwashed several times with water and alcohol
  6. customdried

출처 및 근거

ORD 기록
ord-6aeed64457d44dbab7339ed680c6b5a5
출처 데이터셋
uspto-grants-1997_03
특허 번호
US05610141

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