4-Methoxyphenol → Methacryloylglycylglycine

HRID 978179

반응식

HRID 978179 반응식
[NH2:1][CH2:2][C:3]([NH:5][CH2:6][C:7]([OH:9])=[O:8])=[O:4].[C:10](Cl)(=[O:14])[C:11]([CH3:13])=[CH2:12].[OH-].[Na+].COC1C=CC(O)=CC=1>>[C:10]([NH:1][CH2:2][C:3]([NH:5][CH2:6][C:7]([OH:9])=[O:8])=[O:4])(=[O:14])[C:11]([CH3:13])=[CH2:12]

참가 물질

5

반응물 4

HCID 90154-MethoxyphenolHCID 11163GlycylglycineHCID 13528Methacryloyl chlorideHCID 14798Sodium Hydroxide

생성물 1

HCID 10241886Methacryloylglycylglycine

실험 절차

The procedure described above is utilized with 132 g (0.1 mol) of glycylglycine, 105 g of methacryloyl chloride, 80 g of sodium hydroxide and 500 mg of p-methoxyphenol at 0°-5° C. White precipitate is formed from the reaction mixture. The precipitate crystallized from water had a melting point of (192°-196° C.). Yield of product was 150 g (70.8%). NMR (DMSO-d6), 11 gamma (s, 1H, COOH), 7.9 gamma (s, 2H, NH), 5.5 gamma (s, 1H, =CH2C), 5.2 gamma (s, 1H, =CH2), 3.5 gamma (d, 4H, CH2), 2.6 gamma (s, 3H, CH3).

후처리

  1. customWhite precipitate is formed from the reaction mixture
  2. customThe precipitate crystallized from water
  3. customa melting point of (192°-196° C.)

출처 및 근거

ORD 기록
ord-7512288f4ae64b6b97219e387bba9822
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04663409

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