Hydrochloric Acid → 2-Amino-4-ethylbenzoic acid

반응식

[CH2:1]([C:3]1[CH:11]=[C:10]2[C:6]([C:7](=[O:13])C(=O)[NH:9]2)=[CH:5][CH:4]=1)[CH3:2].[OH-:14].[Na+].OO.Cl>>[CH2:1]([C:3]1[CH:11]=[C:10]([NH2:9])[C:6](=[CH:5][CH:4]=1)[C:7]([OH:13])=[O:14])[CH3:2]

참가 물질

반응물 4

HCID 313Hydrochloric Acid

HCID 784Hydrogen Peroxide

HCID 14798Sodium Hydroxide

HCID 138270836-ethyl-1H-indole-2,3-dione

생성물 1

HCID 138270842-Amino-4-ethylbenzoic acid

반응 조건

온도: 50 °C

실험 절차

In a 500 ml flask, was placed 16.84 gm of 6-ethyl isatin which was covered with 216 ml of 1.5M sodium hydroxide solution. With stirring, the mixture was warmed to 50° C. Heating was discontinued and the solution was treated with a 30% solution of hydrogen peroxide (24 ml) which was added at such a rate to maintain the temperature at between 50° to 65° C. The mixture was left to slowly cool to room temperature and was then acidified to pH 4 with concentrated hydrochloric acid. The precipitated product was then collected by filtration: mp. 117°-120° C.; yield 8.93 gm.