Propanoyl bromide, 2-bromo- → 6-(2-Bromopropionyl)-3,4-dihydro-3-methyl-2(1H)-quinazolinone

HRID 979057

반응식

HRID 979057 반응식
[Br:1][CH:2]([CH3:6])[C:3](Br)=[O:4].[CH3:7][N:8]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][C:9]1=[O:18].[Cl-].[Al+3].[Cl-].[Cl-]>C(=S)=S>[Br:1][CH:2]([CH3:6])[C:3]([C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:18])[N:8]([CH3:7])[CH2:17]2)=[O:4]

참가 물질

5

반응물 3

HCID 79047Propanoyl bromide, 2-bromo-HCID 38465583,4-Dihydro-3-methyl-2(1H)-quinazolinoneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 138271666-(2-Bromopropionyl)-3,4-dihydro-3-methyl-2(1H)-quinazolinone

시약·촉매·용매 1

HCID 6348Carbon Disulfide용매

실험 절차

2-Bromopropionyl bromide (6.7 g) is added dropwise to a stirring mixture of 3,4-dihydro-3-methyl-2(1H)-quinazolinone (2.5 g) and anhydrous aluminum chloride (4.9 g) in carbon disulfide (50 ml) under nitrogen. The reaction mixture is refluxed for five hours, cooled to RT, the carbon disulfide decanted, and the residue treated with hydrochloric acid (6N). The treated residue is poured into ice water, and the resulting suspension is stirred, filtered, the filtered solid washed with water, and dried in vacuo, affording the desired product, which is used in the next step without further purification, M.P. 150°-165° C. (dec).

후처리

  1. temperatureThe reaction mixture is refluxed for five hours
  2. customthe carbon disulfide decanted
  3. additionthe residue treated with hydrochloric acid (6N)
  4. additionThe treated residue is poured into ice water
  5. filtrationfiltered
  6. washthe filtered solid washed with water
  7. customdried in vacuo

출처 및 근거

ORD 기록
ord-9da76f7a64844b85b6eca56b74afeecd
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04666913

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