Sodium Dithionite → 4-chloro-3-hydroxy-10H-phenothiazine

HRID 979076

반응식

HRID 979076 반응식
[O-]S(S([O-])=O)=O.[Na+].[Na+].[Cl:9][C:10]1[C:11](=[O:24])[CH:12]=[CH:13][C:14]2[C:23]=1[S:22][C:21]1[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=1)[N:15]=2>O.CN(C=O)C>[Cl:9][C:10]1[C:23]2[S:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[NH:15][C:14]=2[CH:13]=[CH:12][C:11]=1[OH:24]

참가 물질

5

반응물 2

HCID 24489Sodium DithioniteHCID 117767483H-Phenothiazin-3-one, 4-chloro-

생성물 1

HCID 98814184-chloro-3-hydroxy-10H-phenothiazine수율 95%

시약·촉매·용매 2

HCID 962Water용매2회HCID 6228Dimethylformamide용매

실험 절차

A solution of Na2S2O4 (70 g) in water (500 ml) was added to a solution of 4-chloro-3H-phenothiazin-3-one (50 g) in DMF (1200 ml). The reaction mixture was stirred at room temperature for 3 hours and then poured in 5 liters of water. The resulting precipitate was then filtered to give the 4-chloro-3-hydroxy-10H-phenothiazine (95%). m.p.: 110° C.

후처리

  1. filtrationThe resulting precipitate was then filtered

출처 및 근거

ORD 기록
ord-59864131e5c34b0582e817f322c40d52
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04666907

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