Sodium Hydroxide → HCID 13851426, 화합물
반응식
[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[S:10][CH2:11][CH2:12][C:13]([OH:15])=O.[OH-].[Na+]>C(Cl)(Cl)Cl>[CH3:9][O:8][C:6]1[CH:7]=[C:2]([CH3:1])[C:3]2[S:10][CH2:11][CH2:12][C:13](=[O:15])[C:4]=2[CH:5]=1참가 물질
4
실험 절차
A solution of 21.1 g 3-[(2-methyl-4-methoxyphenyl)thio]propanoic acid and 160 g polyphosphoric ester in 150 ml CHCl3 is refluxed for 45 min. To the cooled reaction mixture is added 200 ml 0.5 N NaOH. The organic phase is separated and the aqueous phase is extracted with 100 ml CHCl3. The combined organic extracts are dried over Na2SO4, filtered, concentrated under reduced pressure and flash chromatrographed with ethyl acetate/hexane (8:92) to yield 6-methoxy-8-methyl-2H-[1]benzothiopyran-4-one.
후처리
- customTo the cooled reaction mixture
- customThe organic phase is separated
- extractionthe aqueous phase is extracted with 100 ml CHCl3
- dry with materialThe combined organic extracts are dried over Na2SO4
- filtrationfiltered
- concentrationconcentrated under reduced pressure and flash
출처 및 근거
- ORD 기록
- ord-61e2149a19f14ec29612012cdcb98da1
- 출처 데이터셋
- uspto-grants-1987_05
- 특허 번호
- US04666916
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