3-Nitrobenzenesulfonic acid → 6-[5-(Imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone

HRID 979283

반응식

HRID 979283 반응식
[N:1]1([CH2:6][C:7]2[S:11][C:10]([C:12]3[CH2:13][CH2:14][C:15](=[O:18])[NH:16][N:17]=3)=[CH:9][CH:8]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[Na].[N+](C1C=C(S(O)(=O)=O)C=CC=1)([O-])=O.[OH-].[Na+]>C(O)(=O)C.O>[N:1]1([CH2:6][C:7]2[S:11][C:10]([C:12]3[CH:13]=[CH:14][C:15](=[O:18])[NH:16][N:17]=3)=[CH:9][CH:8]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

참가 물질

7

반응물 4

HCID 73873-Nitrobenzenesulfonic acidHCID 14798Sodium HydroxideHCID 5360545SodiumHCID 131167414.5-dihydro-6-[5-(imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone

생성물 1

HCID 133702416-[5-(Imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

실험 절차

20 g of 4.5-dihydro-6-[5-(imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone (EP No. 71 059, Example 1) are stirred under reflux together with 19.5 g of the sodium salt of 3-nitrobenzenesulfonic acid and 13.5 g of sodium hydroxide in b 250 ml of water for 1 hour. Thereafter, while the solution is still hot, acetic acid are added until pH 6.9. The solid material precipitated after cooling is filtered of with suction, washed with water and dried.

후처리

  1. customThe solid material precipitated
  2. temperatureafter cooling
  3. filtrationis filtered of with suction
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-8cd74c40b3eb45159312de40f7833fbe
출처 데이터셋
uspto-grants-1987_05
특허 번호
US04667033

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