Hydrogen Bromide → 2-Bromo-1-(4-chlorophenyl)-2-methylpropan-1-one
반응식
[BrH:1].[CH:2]([C:5]([C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1)=[O:6])([CH3:4])[CH3:3].BrBr>C(Cl)(Cl)Cl>[Cl:13][C:10]1[CH:9]=[CH:8][C:7]([C:5]([C:2]([Br:1])([CH3:4])[CH3:3])=[O:6])=[CH:12][CH:11]=1참가 물질
5
실험 절차
1 ml of hydrogen bromide/glacial acetic acid is added to 65.5 g (0.36 mole) of 4-chlorophenyl isopropyl ketone in 200 ml of chloroform and then 57.5 g (0.36 mole) of bromine is added dropwise at 30° C. The mixture is allowed to stir at room temperature for 30 minutes and then evaporated in vacuo. 86.6 g (92% of theory) of crude 2-bromo-2-propyl 4-chlorophenyl ketone are obtained, which is immediately reacted further.
후처리
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-6dbbb0fabf7e452da4e339a0c9a43235
- 출처 데이터셋
- uspto-grants-1987_05
- 특허 번호
- US04668660
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