Succinic anhydride → 4-(3,5-Dimethyl-4-methoxyphenyl)-4-oxobutyric acid

HRID 980755

반응식

HRID 980755 반응식
[C:1]1(=[O:7])[O:6][C:4](=[O:5])[CH2:3][CH2:2]1.[CH3:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[C:10]=1[O:16][CH3:17].[Cl-].[Cl-].[Cl-].[Al+3]>ClCCCl>[CH3:8][C:9]1[CH:14]=[C:13]([C:4](=[O:5])[CH2:3][CH2:2][C:1]([OH:6])=[O:7])[CH:12]=[C:11]([CH3:15])[C:10]=1[O:16][CH3:17]

참가 물질

5

반응물 3

HCID 7922Succinic anhydrideHCID 660882,6-DimethylanisoleHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 140320874-(3,5-Dimethyl-4-methoxyphenyl)-4-oxobutyric acid

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

반응 조건

온도
0 °C

실험 절차

Succinic anhydride (22.06 gm) was added to a mixture of 2,6-dimethylanisole (30 g) and anhydrous aluminium trichloride (59 g) in 1,2-dichloroethane (200 ml) at 0° C. The mixture was stirred for 0.5 hr at 0° C. and at room temperature for 4 hr. The mixture was poured onto ice-concentrated hydrochloric acid. After stirring vigorously for 5 min, the mixture was extracted with ethyl acetate. The dried (MgSO4) organic fraction was evaporated to give 4-(3,5-dimethyl-4-methoxyphenyl)-4-oxobutyric acid as white crystals, mp 108° C.

후처리

  1. additionThe mixture was poured onto ice-concentrated hydrochloric acid
  2. stirringAfter stirring vigorously for 5 min
  3. extractionthe mixture was extracted with ethyl acetate
  4. dry with materialThe dried (MgSO4) organic fraction
  5. customwas evaporated

출처 및 근거

ORD 기록
ord-56eeba886a3c4caca4bf9402fed19c29
출처 데이터셋
uspto-grants-1987_01
특허 번호
US04639267

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