Hydrochloric Acid → 1-Aminomethyl-5-acetoxy-3-phenyl-3,4dihydronaphthalene hydrochloride

HRID 982094노트

반응식

HRID 982094 반응식
C(O)=O.[NH2:4][CH2:5][C:6]1[C:15]2[C:10](=[C:11]([OH:16])[CH:12]=[CH:13][CH:14]=2)[CH2:9][CH:8]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:7]=1.NCC1C2[C:29](=[C:30]([OH:35])C=CC=2)CC(C2C=CC=CC=2)C=1.[ClH:42]>C(OC(=O)C)(=O)C>[ClH:42].[NH2:4][CH2:5][C:6]1[C:15]2[C:10](=[C:11]([O:16][C:30](=[O:35])[CH3:29])[CH:12]=[CH:13][CH:14]=2)[CH2:9][CH:8]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 200690411-Aminomethyl-5-hydroxy-3-phenyl-3,4-dihydronaphthaleneHCID 200690431-Aminomethyl-5-hydroxy-3-phenyl-3,4-dihydronaphthalene formic acid salt

생성물 1

HCID 200690701-Aminomethyl-5-acetoxy-3-phenyl-3,4dihydronaphthalene hydrochloride

시약·촉매·용매 1

HCID 7918Acetic Anhydride용매

실험 절차

A suspension of 1-aminomethyl-5-hydroxy-3-phenyl-3,4-dihydronaphthalene formic acid salt, the product of Example 2, in acetic anhydride saturated with anhydrous hydrogen chloride is stirred at ambient temperature for 48 h. A solid is collected by filtration and washed with diethyl ether. Crystallization of the crude material is achieved by dissolving the powder in hot ethanol, adding water, filtering the solution hot and allowing it to cool. Filtration and drying of the solid collected affords 1-aminomethyl-5-acetoxy-3-phenyl-3,4dihydronaphthalene hydrochloride.

후처리

  1. filtrationA solid is collected by filtration
  2. washwashed with diethyl ether
  3. customCrystallization of the crude material
  4. dissolutionby dissolving the powder in hot ethanol
  5. additionadding water
  6. filtrationfiltering the solution hot
  7. temperatureto cool
  8. filtrationFiltration
  9. customdrying of the solid
  10. customcollected

출처 및 근거

ORD 기록
ord-7146eb8919b24b5283fe3bd2333e53fd
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04994486

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