Hydrochloric Acid → 2-(4-ethoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic Acid

HRID 982640노트

반응식

HRID 982640 반응식
C[O:2][C:3]([C:5]1[C:6]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH3:22])=[CH:16][CH:15]=2)=[N:7][N:8]2[C:13]=1[CH:12]=[CH:11][CH:10]=[N:9]2)=[O:4].[OH-].[Na+].Cl>C(O)C>[CH2:21]([O:20][C:17]1[CH:18]=[CH:19][C:14]([C:6]2[C:5]([C:3]([OH:4])=[O:2])=[C:13]3[N:8]([N:9]=[CH:10][CH:11]=[CH:12]3)[N:7]=2)=[CH:15][CH:16]=1)[CH3:22]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 542755002-(4-ethoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic Acid Methyl Ester

생성물 1

HCID 225623382-(4-ethoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic Acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2-(4-ethoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic acid methyl ester (1.2 g), ethanol (10 ml) and 2N sodium hydroxide (10 ml) was heated to 80° for 1.5 h. The mixture was allowed to cool and acidified to pH 1 with 2N hydrochloric acid. The title compound was isolated by filtration as a brown solid (716 mg, 63%).

후처리

  1. temperaturewas heated to 80° for 1.5 h
  2. temperatureto cool

출처 및 근거

ORD 기록
ord-02247d0a45b849c5a7d5cd5b1ca83dcc
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06861429B2

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