Hexylamine → [2-(Hexylamino)phenyl]methanol

HRID 984680

반응식

HRID 984680 반응식
Br[C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5].[CH2:10]([NH2:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]>>[CH2:10]([NH:16][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]

참가 물질

3

반응물 2

HCID 8102HexylamineHCID 728502-Bromobenzyl alcohol

생성물 1

HCID 15084054[2-(Hexylamino)phenyl]methanol수율 81%

실험 절차

Using the general procedure, 2-bromobenzyl alcohol (187 mg, 1.0 mmol) was coupled with n-hexylamine (198 μL, 1.5 mmol) at 90° C. for 22 h. Purification of the crude product by column chromatography on silica gel using hexane/ethyl acetate (6:1) as eluent afforded the desired product as a colorless liquid (168 mg, 81% yield). Rf=0.7 (hexane/ethyl acetate=2:1).

후처리

  1. customPurification of the crude product by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-d5ec20fddb934fe3adb416f27f404e0f
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06867298B2

연결된 노트

불러오는 중…