Ethanol → 3,4-Dihydroxythiophene-2,5-dicarboxylic acid

HRID 984761

반응식

HRID 984761 반응식
CCO.[C:4]([C:9]1[S:10][C:11]([C:16]([O:18]CC)=[O:17])=[C:12]([OH:15])[C:13]=1[OH:14])([O:6]CC)=[O:5].[OH-].[Na+]>O>[C:16]([C:11]1[S:10][C:9]([C:4]([OH:6])=[O:5])=[C:13]([OH:14])[C:12]=1[OH:15])([OH:18])=[O:17]

참가 물질

5

반응물 3

HCID 702Ethanol2회HCID 14798Sodium HydroxideHCID 2455033,4-Dihydroxy-thiophene-2,5-dicarboxylic acid diethyl ester

생성물 1

HCID 3162693,4-Dihydroxythiophene-2,5-dicarboxylic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

EtOH (30 mL) was added to 2,5-dicarbethoxy-3,4-dihydroxythiophene (1 g). A solution of NaOH (4.0 g) in H2O (20 mL) was added and refluxed under N for 20 h. Upon cooling to ambient temperature the EtOH was removed by distillation and the residue was redissolved in H2O then acidified with 15% HClaq when a white ppt was obtained This product was collected by filtration and washed with cold H2O then crystallized from dilute MeOH to give colorless needles.

후처리

  1. temperaturerefluxed under N for 20 h
  2. customwas removed by distillation
  3. dissolutionthe residue was redissolved in H2O
  4. customwas obtained This product
  5. filtrationwas collected by filtration
  6. washwashed with cold H2O
  7. customthen crystallized from dilute MeOH
  8. customto give colorless needles

출처 및 근거

ORD 기록
ord-0e1c8a71196d4753a61e5b592f8c8adb
출처 데이터셋
uspto-grants-2005_03
특허 번호
US06869729B1

연결된 노트

불러오는 중…