Sodium Hydroxide → 6-Bromo-2-methoxyquinoline
반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[CH:6]=[CH:5]2.F[B-](F)(F)F.[CH3:18][O+](C)C.[OH-].[Na+]>ClCCl>[CH3:18][O:12][C:7]1[CH:6]=[CH:5][C:4]2[C:9](=[CH:10][CH:11]=[C:2]([Br:1])[CH:3]=2)[N:8]=1참가 물질
5
실험 절차
A mixture of 6-bromo-2-[1H]-quinolone (2.90 g) and trimethyloxoniumtetrafluoroborate (2.10 g) was stirred in dichloromethane (50 cm3) for 48 hours under nitrogen. Aqueous 10% sodium hydroxide (20 cm3) was added and the aqueous phase was extracted with dichloromethane (2×40 cm3). The dried (MgSO4) extracts were evaporated and the residue was crystallised from petroleum ether (b.p. 60°-80°) to yield 2-methoxy-6-bromoquinoline, m.p. 90°-94°, (2.16 g).
후처리
- extractionthe aqueous phase was extracted with dichloromethane (2×40 cm3)
- dry with materialThe dried (MgSO4) extracts
- customwere evaporated
- customthe residue was crystallised from petroleum ether (b.p. 60°-80°)
출처 및 근거
- ORD 기록
- ord-199d7d70815b4cc98a0cae6d0606db50
- 출처 데이터셋
- uspto-grants-1987_12
- 특허 번호
- US04710507
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