Chloroacetic Acid → Benzimidazole, 2-chloromethyl-5,6-dichloro-

HRID 986664

반응식

HRID 986664 반응식
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH2:9])=[C:4]([NH2:10])[CH:3]=1.[Cl:11][CH2:12][C:13](O)=O>Cl>[Cl:11][CH2:12][C:13]1[NH:10][C:4]2[CH:3]=[C:2]([Cl:1])[C:7]([Cl:8])=[CH:6][C:5]=2[N:9]=1

참가 물질

4

반응물 2

HCID 300Chloroacetic AcidHCID 792974,5-Dichloro-1,2-phenylenediamine

생성물 1

HCID 38349Benzimidazole, 2-chloromethyl-5,6-dichloro-수율 80.7%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 1.77 g (10 m mol) of 4,5-dichloro-1,2-phenylenediamine in 15 ml of 4N aqueous hydrochloric acid was stored at room temperature overnight. To the solution was added 1.42 g (15 m mol) of monochloroacetic acid, and refluxed for 3 hours and filtered. The filterate was cooled to room temperature, stirred and rendered alkaline by addition of ammonium hydroxide. The separated precipitate was washed with water and dried to give 1.9 g (68%) of the title compound.

후처리

  1. temperaturerefluxed for 3 hours
  2. filtrationfiltered
  3. additionby addition of ammonium hydroxide
  4. washThe separated precipitate was washed with water
  5. customdried

출처 및 근거

ORD 기록
ord-6f3ea686ca0c44848b783cb11ef233c2
출처 데이터셋
uspto-grants-1987_12
특허 번호
US04714764

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