Sodium Hydroxide → 7-Thienylamino-1H-pyrazolo[4,3-b]pyridine

HRID 986746

반응식

HRID 986746 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[NH:6][C:7]1[C:12](C(OCC)=O)=[CH:11][N:10]=[C:9]2[CH:18]=[N:19][NH:20][C:8]=12.[OH-].[Na+]>C(O)C>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]2[CH:18]=[N:19][NH:20][C:8]=12

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 20156241Ethyl 7-thienylamino-1H-pyrazolo[4,3-b]pyridine-6-carboxylate

생성물 1

HCID 201562447-Thienylamino-1H-pyrazolo[4,3-b]pyridine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl 7-thienylamino-1H-pyrazolo[4,3-b]pyridine-6-carboxylate (0.600 g) was converted to the corresponding acid by heating under reflux with a 2% sodium hydroxide solution in ethanol (50 ml). The ethanol was removed under reduced pressure and the residue diluted with water (5 ml) and acidified to pH5 with dilute hydrochloric acid. The resulting acid was filtered off and dried, mp 255°-259° C.

후처리

  1. temperatureby heating
  2. customThe ethanol was removed under reduced pressure
  3. additionthe residue diluted with water (5 ml)
  4. filtrationThe resulting acid was filtered off
  5. customdried

출처 및 근거

ORD 기록
ord-795da91dd8ec4d3bba0d28a4380803d5
출처 데이터셋
uspto-grants-1987_12
특허 번호
US04716160

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