Sodium Hydroxide → 7-Thienylamino-1H-pyrazolo[4,3-b]pyridine
반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[NH:6][C:7]1[C:12](C(OCC)=O)=[CH:11][N:10]=[C:9]2[CH:18]=[N:19][NH:20][C:8]=12.[OH-].[Na+]>C(O)C>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]2[CH:18]=[N:19][NH:20][C:8]=12참가 물질
4
실험 절차
Ethyl 7-thienylamino-1H-pyrazolo[4,3-b]pyridine-6-carboxylate (0.600 g) was converted to the corresponding acid by heating under reflux with a 2% sodium hydroxide solution in ethanol (50 ml). The ethanol was removed under reduced pressure and the residue diluted with water (5 ml) and acidified to pH5 with dilute hydrochloric acid. The resulting acid was filtered off and dried, mp 255°-259° C.
후처리
- temperatureby heating
- customThe ethanol was removed under reduced pressure
- additionthe residue diluted with water (5 ml)
- filtrationThe resulting acid was filtered off
- customdried
출처 및 근거
- ORD 기록
- ord-795da91dd8ec4d3bba0d28a4380803d5
- 출처 데이터셋
- uspto-grants-1987_12
- 특허 번호
- US04716160
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