Hydrochloric Acid → 4-Chloro-6,7-dimethoxyquinoline-3-carboxylic acid

HRID 989055노트

반응식

HRID 989055 반응식
C([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[Cl:16])=[CH:13][C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=2)=[O:5])C.[OH-].[Na+].Cl>C(O)C.O>[Cl:16][C:15]1[C:14]2[C:9](=[CH:10][C:11]([O:19][CH3:20])=[C:12]([O:17][CH3:18])[CH:13]=2)[N:8]=[CH:7][C:6]=1[C:4]([OH:5])=[O:3]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 103571783-Carbethoxy-4-chloro-6,7-dimethoxylquinoline

생성물 1

HCID 180050224-Chloro-6,7-dimethoxyquinoline-3-carboxylic acid수율 116.4%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

4-chloro-6,7-dimethoxy-3-quinolinecarboxylic ethyl ester (ex RSL) (50 g) was suspended in ethanol (400 ml) and aqueous 2M sodium hydroxide (400 ml) was added with stirring, stirred for 24 hours. The reaction mixture was diluted with water (400 ml), cooled in an ice/water bath and brought to pH4 by carefully addition of concentrated hydrochloric acid. The resulting solid was filtered off, washed with water and dried in a vacuum oven at 50° C. To give 4-chloro-6,7-dimethoxy-3-quinolinecarboxylic acid (52.7 g, 98.7%).

후처리

  1. stirringstirred for 24 hours
  2. temperaturecooled in an ice/water bath
  3. filtrationThe resulting solid was filtered off
  4. washwashed with water
  5. customdried in a vacuum oven at 50° C

출처 및 근거

ORD 기록
ord-88e97d518c1b403e8554a7da5a29042a
출처 데이터셋
uspto-grants-2003_10
특허 번호
US06638945B1

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