Hydrochloric Acid → 1-Methylpiperidine-2-carboxylic acid

HRID 989605

반응식

HRID 989605 반응식
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][N:7]1[CH3:12])=[O:5])C.[OH-].[Na+].Cl>CO.O>[CH3:12][N:7]1[CH2:8][CH2:9][CH2:10][CH2:11][CH:6]1[C:4]([OH:5])=[O:3]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 566742Ethyl 1-methylpiperidine-2-carboxylate

생성물 1

HCID 4159391-Methylpiperidine-2-carboxylic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

N-Methyl-piperidine-2-carboxylic acid ethyl ester (5.1 g) was dissolved in a mixture of 100 ml methanol and 10 ml water. NaOH (8 g) was added and the reaction mixture was stirred at room temperature overnight. The solution was then neutralized with hydrochloric acid, evaporated to dryness, and evaporated four times with toluene. The resulting powdery residue was used directly in the next step.

후처리

  1. customevaporated to dryness
  2. customevaporated four times with toluene

출처 및 근거

ORD 기록
ord-753b8025e5bc4004b6a994e37a6235ee
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06458765B1

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